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Comparison of Convolutional Neural Network Model for Brain Tumor Disease Gliome Detection

Author(s): Wulan Sallyndri Santoso , Riko Arlando Saragih ORCID https://orcid.org/0000-0003-2617-9363
Author(s) information:
Electrical Engineering Department, Universitas Kristen Maranatha, Bandung, Indonesia

Corresponding author

Glioma represented one of the most aggressive forms of malignant brain tumors, necessitating early detection to optimize therapeutic intervention outcomes. Manual tumor identification through Magnetic Resonance Imaging (MRI) was labor-intensive and was susceptible to subjective interpretation errors. This study aimed to compare the performance of two Convolutional Neural Network (CNN) architectures, specifically Residual Network (ResNet) and U-Net, for glioma tumor detection in T2-weighted MRI sequences. The datasets employed were obtained from the BraTS and Kaggle repositories and underwent comprehensive preprocessing procedures, including normalization, augmentation, and conversion to Portable Network Graphics (PNG) format. The evaluation metrics demonstrated that the U-Net architecture exhibited superior performance compared to ResNet-18, achieving an accuracy of 88.16%, sensitivity of 80.00%, specificity of 88.43%, and F1-score of 68.97%. Conversely, ResNet-18 yielded an accuracy of 71.43%, sensitivity of 73.52%, specificity of 81.54%, and an F1-score of 70.14%. These findings indicated that U-Net demonstrated greater efficacy in recognizing tumor morphology within MRI data and preserving spatial information through its inherent skip connection mechanism. This investigation demonstrated the potential of the U-Net architecture to facilitate automated and enhanced accuracy in glioma detection, although further refinement was required to improve segmentation precision and clinical applicability.

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How cancer can spread. (accessed on 9 October 2023) Available online: https://www.cancerresearchuk.org/about-cancer/what-is-cancer/how-cancer-can-spread.

Tumor otak. (accessed on 24 January 2025) Available online: https://www.alodokter.com/tumor-otak.

Epidemiologi tumor otak. (accessed on 17 September 2024) Available online: https://www.alomedika.com/penyakit/onkologi/tumor-otak/epidemiologi.

Penderita tumor otak terus meningkat, FK Unair gandeng ahli bedah saraf Belanda untuk adopsi teknologi terbaru. (accessed on 21 February 2024) Available online: https://www.suarasurabaya.net/kelanakota/2024/penderita-tumor-otak-terus-meningkat-fk-unair-gandeng-ahli-bedah-saraf-belanda-untuk-adopsi-teknologi-terbaru/.

Bordoloi, D.; Singh, V.; Sanober, S.; Buhari, S.M.; Ujjan, J.A.; Boddu, R. (2022). Deep learning in healthcare system for quality of service. Journal of Healthcare Engineering, 2022, 8169203. https://doi.org/10.1155/2022/8169203.

Alowais, S.A.; Alghamdi, S.S.; Alsuhebany, N.; et al. (2023). Revolutionizing healthcare: The role of artificial intelligence in clinical practice. BMC Medical Education, 23, 689. https://doi.org/10.1186/s12909-023-04698-z.

Ronneberger, O.; Fischer, P.; Brox, T. (2015). U-Net: Convolutional networks for biomedical image segmentation. Medical Image Computing and Computer-Assisted Intervention – MICCAI 2015 (Vol. 9351, pp. 234–241); Springer: Cham, Switzerland. https://doi.org/10.1007/978-3-319-24574-4_28.

He, K.; Zhang, X.; Ren, S.; Sun, J. (2016, June). Deep residual learning for image recognition. Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, 770–778. Las Vegas: USA. https://doi.org/10.1109/CVPR.2016.90.

Çiçek, Ö.; Abdulkadir, A.; Lienkamp, S.S.; Brox, T.; Ronneberger, O. (2016). 3D U-Net: Learning dense volumetric segmentation from sparse annotation. In Medical Image Computing and Computer-Assisted Intervention – MICCAI 2016; Springer: Cham, Switzerland; 424–432. https://doi.org/10.1007/978-3-319-46723-8_49.

Powers, D.M.W. (2011). Evaluation: From precision, recall and F measure to ROC, informedness, markedness & correlation. Journal of Machine Learning Technologies, 2, 37–63.

Sokolova, M.; Lapalme, G. (2009). A systematic analysis of performance measures for classification tasks. Information Processing & Management, 45, 427–437. https://doi.org/10.1016/j.ipm.2009.03.002.

Chicco, D.; Jurman, G. (2020). The advantages of the Matthews correlation coefficient (MCC) over F1 score and accuracy in binary classification evaluation. BMC Genomics, 21, 6. https://doi.org/10.1186/s12864-019-6413-7.

Taha, A.A.; Hanbury, A. (2015). Metrics for evaluating 3D medical image segmentation: Analysis, selection, and tool. BMC Medical Imaging, 15, 29. https://doi.org/10.1186/s12880-015-0068-x.

Tharwat, A. (2021). Classification assessment methods. Applied Computing and Informatics, 17, 168–192. https://doi.org/10.1016/j.aci.2018.08.003.

Ronneberger, O.; Fischer, P.; Brox, T. (2015). U-Net: Convolutional networks for biomedical image segmentation. In Medical Image Computing and Computer-Assisted Intervention – MICCAI 2015, Munich, Germany, 5–9 October 2015; Springer: Cham, Switzerland; Volume 9351, pp. 234–241. https://doi.org/10.1007/978-3-319-24574-4_28.

Litjens, G.; Kooi, T.; Bejnordi, B.E.; et al. (2017). A survey on deep learning in medical image analysis. Medical Image Analysis, 42, 60–88. https://doi.org/10.1016/j.media.2017.07.005.

Isensee, F.; Jaeger, P.F.; Kohl, S.A.A.; Petersen, J.; Maier-Hein, K.H. (2021). nnU-Net: A self-configuring method for deep learning-based biomedical image segmentation. Nature Methods, 18, 203–211. https://doi.org/10.1038/s41592-020-01008-z.

Zhou, Z.; Siddiquee, M.M.R.; Tajbakhsh, N.; Liang, J. (2018). UNet++: A nested U-Net architecture for medical image segmentation. Deep Learning in Medical Image Analysis and Multimodal Learning for Clinical Decision Support, Granada, Spain, 20 September 2018; Springer: Cham, Switzerland; pp. 3–11. https://doi.org/10.1007/978-3-030-00889-5_1.

Huang, G.; Sun, Y.; Liu, Z.; et al. (2016). Deep networks with stochastic depth. In European Conference on Computer Vision, Amsterdam, The Netherlands, 11–14 October 2016; Springer: Cham, Switzerland; pp. 646–661. https://doi.org/10.1007/978-3-319-46493-0_39.

Zhang, Z.; Liu, Q.; Wang, Y. (2018). Road extraction by deep residual U-Net. IEEE Geoscience and Remote Sensing Letters, 15, 749–753. https://doi.org/10.1109/LGRS.2018.2802944.

Xie, S.; Girshick, R.; Dollár, P.; Tu, Z.; He, K. (2017). Aggregated residual transformations for deep neural networks. Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, Honolulu, HI, USA, 21–26 July 2017; IEEE: Piscataway, USA, pp. 1492–1500. https://doi.org/10.1109/CVPR.2017.634.

Godlee, R.J. (1884). A successful case of removal of a cerebral tumour with a description of the symptoms produced by a tumour growing in the cerebellum. The Lancet, 1, 128–132.

Pereira, S.; Pinto, A.; Alves, V.; Silva, C.A. (2016). Brain tumor segmentation using convolutional neural networks in MRI images. IEEE Transactions on Medical Imaging, 35, 1240–1251. https://doi.org/10.1109/TMI.2016.2538465.

Essig, M.; Shiroishi, M.S.; Nguyen, T.B.; et al. (2013). Perfusion MRI: The five most frequently asked technical questions. American Journal of Roentgenology, 200, 24–34. https://doi.org/10.2214/AJR.12.9620.

Sheller, M.J.; Edwards, B.; Reina, G.A.; et al. (2020). Federated learning in medicine: Facilitating multi-institutional collaborations without sharing patient data. Scientific Reports, 10, 12598. https://doi.org/10.1038/s41598-020-69250-1.

He, K.; Zhang, X.; Ren, S.; Sun, J. (2016). Deep residual learning for image recognition. In Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, Las Vegas, NV, USA, 27–30 June 2016; IEEE: Piscataway, USA, pp. 770–778. https://doi.org/10.1109/CVPR.2016.90.

Stoyanov, G.S.; Dzhenkov, D.L. (2018). Glioblastoma multiforme—histopathological and molecular characteristics. Folia Medica, 60, 479–493. https://doi.org/10.2478/folmed-2018-0036.

Le Bihan, D.; Johansen-Berg, H. (2012). Diffusion MRI at 25: Exploring brain tissue structure and function. NeuroImage, 61, 324–341. https://doi.org/10.1016/j.neuroimage.2011.11.006.

About this article

SUBMITTED: 16 November 2025
ACCEPTED: 24 February 2026
PUBLISHED: 5 March 2026
SUBMITTED to ACCEPTED: 100 days
DOI: https://doi.org/10.53623/gisa.v6i1.899

Cite this article
Santoso, W. S. ., & Saragih, R. A. (2026). Comparison of Convolutional Neural Network Model for Brain Tumor Disease Gliome Detection. Green Intelligent Systems and Applications, 6(1), 51−64. https://doi.org/10.53623/gisa.v6i1.899
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